Even though we can’t be sure exactly how modafinil works, we know that it stops nerve cells from reabsorbing dopamine, an excitatory neurotransmitter. Its effects match those of stimulants, but it doesn’t cause a “high” or addictive cravings.
In a study of people with narcolepsy, all four modafinil dosing regimens improved their performance on the MWT compared to the placebo baseline. However, the differences were small.
It Helps You Stay Awake
Modafinil Online Australia is a stimulant that boosts brain activity, making patients feel more awake and energetic. It’s used to treat excessive tiredness caused by sleep conditions like narcolepsy, shift work disorder, and obstructive sleep apnea. It’s also prescribed off-label to increase alertness in people with Parkinson’s disease. It can be habit-forming, so people should take smaller doses more often and not exceed the recommended amount.
Modalaine binds weakly and selectively to the dopamine transporter (Mignot et al 1994; Nishino et al 1998) and, at wake-promoting concentrations, increases extracellular levels of dopamine and norepinephrine in certain cerebellar regions of the awake rat brain (de Saint Hilaire et al 2001). Dual probe microdialysis studies suggest that the vigilance-promoting activity of modafinil is due to its ability to amplify the increase in dialysate serotonin induced by the antidepressant drug fluoxetine.
In large-scale, double-blind placebo-controlled studies in SWD and narcolepsy patients, modafinil significantly improved objectively measured wakefulness during the MSLT and MWT and reduced patient-reported sleepiness on the ESS and KSS, without adversely affecting daytime scheduled sleep or cardiovascular parameters. Diary data showed that fewer patients on modafinil reported accidents and near-accidents during the commute home from work, as well as improvements in functional status, health-related quality of life, and mood.
It Helps You Stay Alert
Modafinil has been used to help keep people awake and alert for several conditions. It’s often used as a “smart drug” and cognitive enhancer, especially for high-level executives or stressed-out students, and it has indeed been shown to promote alertness, concentration, and memory in sleep-deprived individuals.
Modafinil is a wake-promoting agent that works by altering the levels of certain chemicals and neurotransmitters in the brain. Its effects are similar to those of stimulants like amphetamine and methylphenidate, but it does not produce the same psychological addiction or dependency.
Several large-scale, double-blind, placebo-controlled clinical studies in patients with OSA (Pack et al 2001; Black and Hirshkowitz 2005), SWD (Czeisler et al 2005; Erman et al 2007), and narcolepsy have demonstrated the efficacy of once-daily doses of 200 to 400 mg of modafinil. In four of these studies, an objective measure of excessive sleepiness (i.e., sleep latency on the Multiple Sleep Latency Test or Maintenance of Wakefulness Test) was chosen as a primary efficacy measure.
Two studies in narcolepsy patients also reported that Modalert 200mg Tablet reduced anxiety. However, modafinil has been associated with an increase in heart rate and tachycardia.
It Helps You Stay Focused
Modafinil’s primary pharmacological effect is to promote wakefulness, which it has been shown to do in studies in animal models of narcolepsy and sleep-disordered breathing and sleep-deprived humans (Black and Hirshkowitz 2005). In addition, the benzyhydrylsulfinylacetamide drug has been found to reduce excessive daytime sleepiness in people with shift work disorder, narcolepsy, and obstructive sleep apnea/sleep apnea syndrome.
Modafinil has also been found to enhance cognitive performance in healthy non-sleep-deprived individuals. In one placebo-controlled study, modafinil 200 mg taken once daily significantly enhanced digit span and visual recognition memory and improved perceptual, arithmetic, and spatial planning tasks without compromising speed-accuracy trade-offs or depressing vigilance.
It is important to note that Modafinil does not cure underlying sleep disorders and should be used only as prescribed by your doctor. Taking the drug in higher doses than your physician prescribes or using it for recreational purposes puts you at risk of developing tolerance to the medication and experiencing negative side effects. It is also important to follow your doctor’s advice about getting sufficient amounts of sleep and continue any other treatment for underlying sleep disorders such as breathing devices or surgery.
It Helps You Stay Active
Modafinil is a wakefulness-promoting agent that has been approved by the FDA for use in conditions like narcolepsy and shift work sleep disorder. It is also sometimes prescribed along with breathing devices to help prevent excessive fatigue caused by obstructive sleep apnea.
Several studies have shown that modafinil increases cognitive performance in healthy people who are not sleep-deprived. These studies have included a variety of tasks, including digit span, visual recognition memory, delayed matching, and spatial planning. Modafinil has been shown to improve these types of tasks without affecting speed or accuracy.
In a series of large, double-blind, placebo-controlled clinical studies for narcolepsy, obstructive sleep apnea, and shift work sleep disorder, modafinil was found to be effective in improving vigilance and alertness. Some common side effects include headache, nausea, rhinitis, infection, anxiety, nervousness, and diarrhea (Roth et al, 2007). As with any medication, it is important to take this drug as directed. Otherwise, you may develop a tolerance to its effects and no longer experience the improved awareness and elevated mood that it produces.
It Helps You Stay Healthy
Modafinil has been shown to improve objectively determined wakefulness on the MWT and subjective sleepiness in several studies. Improvements in cognitive function and health-related quality of life were also observed. The drug is well-tolerated in double-blind, placebo-controlled studies and long-term open-label extensions of the original 4-week OSA study (Schwartz et al 2003c; Black and Hirshkowitz 2005).
Although this medication is less addictive than some other stimulant medications that are derived from amphetamine, it still poses the risk of misuse, dependence, and addiction. It is recommended that patients follow the instructions of their doctor closely and ask for clarification on any part they do not understand.
Caffeine can increase the side effects of this medication, so it is advised that patients do not drink large amounts of caffeine-containing beverages such as coffee, tea, and colas or use nonprescription products containing caffeine (such as cough-and-cold products or diet aids) while taking Modafinil. This medication may cause dizziness, so patients mustn’t drive or operate machinery until they are fully awake.
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